Gene: [20^/PTGIS] prostaglandin I2 (prostacyclin) synthase; cytochrome P450, subfamily VIII (prostacyclin synthase);
COM | Although prostacyclin synthase has absorbance spectral features characteristic of the cytochrome P450s, this enzyme has no monooxygenase activity and does not require an external source of electrons to initiate its enzyme reaction (Wang-1996). PGIS has been named CYP8 in the cytochrome P450 superfamily. The gene is also symbolized PGIS for prostaglandin I2 synthase." |
FUN | The prostacyclin synthase (PGIS) catalyzes the isomerization of prostaglandin H2 to prostacyclin (prostaglandin I2) which is a potent vasodilator and inhibitor of platelet aggregation." |
GEN | The gene length: 60 kb (app.); exons: 10 (Wang-1996). |
MOP | PTGIS encodes a polypeptide of 500 amino acids with sequence homology to cholesterol 7-alpha-monooxygenase (GEM:08q1/CYP7A1), a member of the superfamily of cytochrome P450s (FAM:CYP/00.0)." |
REF | COD,SEQ "Miyata A &: BBRC, 200, 1728-1734, 1994a COD,SEQ "Miyata A &: Cell Mol Biol Res, 200, 1728-1734, 1994b GEN,LOC "Wang L-H, Chen L: BBRC, 226, 631-637, 1996 |
SWI | SWISSPROT: Q16647 |
KEY | xen |
CLA | coding, basic |
LOC | 20 |
MIM | MIM: 601699 |
EZN | ENZYME: 5.3.99.4 |
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